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Gluten Free Dog Food: A Science-based Analysis

Gluten remains a scorching matter, and extra house owners at present are looking for gluten free dog food for their pets, too. Studies show that majority of canine are actually not delicate to gluten, however some undoubtedly are.

A growing body of analysis demonstrated that gluten sensitivity itself is in truth real, and specific diets may help cope with its damaging results. Meals allergic reactions account for about 10% of all allergic reactions in canines, and this consists of sensitivity to gluten.

Over 30% of People have eradicated gluten from their diets, and this development continues into the pet meals market with gluten free pet food turning into extremely popular but pricey.

This article will look at how real gluten sensitivity in canine is, what are the causes and coverings, and whether gluten free dog food might be the reply.

What is Gluten?

Gluten is a mix of two proteins, gliadin and glutenin.

It is found in many grains comparable to wheat, barley, rye and couscous. Wheat is by far the most typical supply of gluten, and gliadin is the primary suspect of most hostile effects (1, 2).

Gluten has a glue-like consistency that helps to type dog kibble. It’s achieved via mixing flour with water (3). There are grains which do not include gluten. These embrace rice, corn, oats, millet and quinoa.

It is very important bear in mind that a gluten free canine eating regimen will not be grain free, but a grain free food plan will all the time be gluten free.

Surveys show that over a third of People try to get rid of gluten from their food plan, and many homeowners try and do the same with their pet meals.

Summary: Gluten is a mixture of two proteins and is usually present in grains comparable to wheat, rye and barley. Gliadin in gluten is answerable for a lot of the damaging effects.

Why is Gluten Dangerous for Canine and Individuals?

Gluten isn’t necessarily all-bad. However earlier than we will analyze why gluten could also be harmful to canine, we’d like to try where this gluten free development comes from, and that’s human food regimen.

The truth is that majority of pets and other people, together with lots of these at present on a gluten free weight loss plan, can truly tolerate gluten simply high-quality. Nevertheless, several reviews have found many illnesses related to both gluten or wheat (4).

Generally, particular well being circumstances will end in negative effects from consuming gluten. For individuals, the three commonest circumstances where gluten ought to be prevented are:

  • Celiac illness
  • Gluten sensitivity
  • Irritable Bowel Syndrome (IBS)

Word that the identical breakdown can’t be replicated with canine, and we’ll talk about this under.

Celiac illness (CD) is by far probably the most well-known purpose to avoid gluten (5). CD may cause quite a lot of immune system and intestine related issues (6, 7, 8, 9, 10, 11). Nevertheless, it’s rare in pets. In reality, there’s no document of canine ever creating celiac disease.

Non-celiac gluten sensitivity, which has additionally been observed in canine in several types, remains undefined and should not even be real in people the place the signs are brought on by one thing aside from gluten.

There have been tons of studies of non-celiac gluten sensitivity (12, 13, 14, 15, 16). However a serious research discovered that out of 400 sufferers experiencing “gluten sensitivity,” only 55 individuals truly had problems with consuming gluten (17).

This remains by far probably the most applicable gluten related situation for canine and different pets.

Irritable Bowel Syndrome (IBS) is one more reason to avoid gluten (18, 19, 20, 21, 22, 23). Irritable Bowel Illness (IBD) present in canine has been proven to be totally different to human IBS (24). There’s also no evidence at present out there that gluten may cause IBD in canine, or worsen a pre-existing condition in canine (25, 26, 27, 28).

Research on gluten sensitivity in canine continues to be in its infancy, and these studies from human trials will help us higher understand what could be the explanation for opposed results from gluten in canines.

Abstract: Gluten sensitivity in canine is totally different to that in individuals. Nevertheless, present studies on gluten consumption in human inhabitants might further explain how and why canine are delicate to gluten.

Gluten Sensitivity in Canine

Research have found that gluten intolerance in canine undoubtedly exist, but is primarily genetic, which is comparable but not similar to what the case is with individuals (29, 30, 31, 32, 33).

Gluten is digested in the dog’s small gut by pancreatic enzymes. When a canine suffers from gluten sensitivity, the presence of gluten in the weight-reduction plan causes an inflammatory response in the intestine.

Canine’s intestine irritation has several consequences, including:

  • The atrophy (wasting) of the villi (small projections) in the lining of the small gut chargeable for helping canine’s body to absorb vitamins from meals.
  • An increase in the numbers of lymphocytes (a kind of white blood cell), that are present within the canine’s gut wall (34).

This injury to the gut could make it more durable for vitamins to be absorbed, ultimately resulting in malnutrition and weight loss in canines. Extra unpleasant gastrointestinal symptoms may additionally occur, akin to diarrhea and vomiting. Other signs like pores and skin circumstances are potential, depending on the severity of the allergy (35).

In different varieties of gluten sensitivity in canine, this process may cause the body to supply anti-gliadin and anti-transglutaminase antibodies. They then enter the circulation, and react and launch an autoimmune attack within the canine’s physique.

That is essential as these antibodies can assault elements of the canine’s nervous system, inflicting neurological signs corresponding to ataxia, paroxysmal movement issues (irregular actions during an episode) and even epilepsy.

In recent times, science has made progress on the mechanisms of gluten sensitivity each in people and pets, but it is nonetheless not completely understood.  e additionally need to take a look at correlation between FODMAPs and canine with gluten sensitivity (36).

Some individuals with gluten points have been truly delicate to FODMAPs and not gluten, which finally presents an fascinating case to review in pets as properly (37).

Abstract: Gluten intolerance in canine is genetic. Presence of gluten in a food regimen of gluten delicate canine can have many detrimental health effects. Different wheat-related causes of meals allergic reactions in canine are additionally attainable.

Is Gluten Free Dog Meals Important?

Gluten just isn’t necessarily dangerous for all canine, thus a gluten free pet food weight-reduction plan isn’t all the time essential. The grains that include gluten could be a perfectly good supply of carbohydrate, protein, fiber, hint minerals in addition to vitamins B and E when forming part of a balanced canine food plan (38).

Nevertheless, research have shown that many animals may be delicate to gluten, and a gluten free weight-reduction plan might considerably improve well being of these patients (39, 40, 41, 42). Evidence is clear that gluten free dog food can undoubtedly assist canine with gluten sensitivity.

Most canine aren’t delicate to gluten

A current rise in perceived meals intolerance in people and the fashion for individuals to stick to gluten free diets has seen an growing variety of house owners eager to comply with these developments with their canine as properly (43, 44, 45).

Regardless of the popularity, there isn’t a scientific evidence to help that a gluten free canine weight-reduction plan is completely vital to the overall wholesome canine inhabitants.

Subsequently, majority of householders don’t have to worry about purchasing gluten free canine meals. Nevertheless, there are instances (discussed under) where going gluten-free is required for a dog, and other reasons the place this could merely be a more sensible choice.

On a separate word, a faculty of thought also exist with the beliefs based mostly round what canine would eat in the wild, and gluten sensitivity is usually part of that debate.

The main argument there’s that since canine would not have consumed grains within the wild, then grains shouldn’t be fed as part of their business food plan. Nevertheless, there’s proof to the contrary. Canine are shown to have genes which permit them to readily digest carbohydrates within the type of starch and subsequently grains (46, 47).

Summary: A gluten free food regimen can significantly improve health of canine which are delicate to gluten or wheat-related foods. Gluten free weight-reduction plan just isn’t crucial for wholesome canine that can tolerate gluten, however could also be useful for different reasons.

When is Gluten Free Dog Meals Useful?

Sadly, food allergic reactions in canine, akin to gluten sensitivity, can’t be prevented (48). The equivalent to celiac disease in canine is uncommon. Nevertheless, there are some particular instances where it might be useful for canine to avoid gluten, and feed a gluten free dog food.

Gluten free pet food may be useful for:

  • Breeds with recognized sensitivities
  • Canine with allergic reactions to gluten
  • Canine with epilepsy

Let’s take a better take a look at all three of these instances.

Breeds with recognized gluten sensitivities

There are specific canine breeds which have genetic predisposition to gluten sensitivity.

Irish Setters: Some Irish Setter canine are born with a genetic gluten delicate enteropathy (49, 50, 51, 52).

In some instances this seems to be age-related, and as they attain adult hood they are not affected (53, 54). The rationale for this is at present unknown. Although the situation is genetic, it isn’t associated to the identical genes as in human celiac disease (55).

Gentle Coated Wheaten Terriers: It appears that SCWTs are additionally genetically delicate to gluten or gluten-related compounds.

Particularly, gluten sensitivity may be a think about genetic protein-losing enteropathy (PLE), and protein-losing nephropathy (PLN) associated with this breed (52, 56, 57, 58, 59).

PLE is a condition where the gut becomes broken and a large amount of protein leaks out and is lost. PLN is a situation with an identical idea as PLE but protein is misplaced into the urine as an alternative.

Border Terriers: Some Border Terriers endure from epileptoid cramping syndrome which is a kind of paroxysmal movement dysfunction (abnormal actions throughout an episode) (60).

The cause is presently unknown but these canine have been discovered to have a kind of gluten sensitivity which can be liable for affecting canine’s nervous system (40).

Within the above three breeds, a correctly balanced gluten free pet food eating regimen is probably a sensible choice right from the beginning of adoption or start.

Canine with allergic reactions to gluten

As we’ve got already concluded, it’s undoubtedly attainable for canine to be allergic to gluten. Nevertheless, probably the most regularly recognized dietary allergens in canine are usually not grains but fairly of meat origin, particularly beef, and subsequently are usually not gluten associated (61, 48).

Once you determine that a dog undoubtedly suffers from gluten (more on how to try this under), then it’s time to utterly change to a gluten free pet food weight loss plan.

The most typical signs associated with dietary and gluten associated allergic reactions in canine are sometimes skin associated (62). Symptoms of canine gluten allergy to watch out for embrace:

  • Itchiness
  • Extreme hair loss
  • Bald patches
  • Infected pores and skin
  • Sores and scabs
  • “Hot spots” (pink, irritated, itchy areas)

Keep in mind that these indicators are additionally widespread to many other varieties of allergic reactions in canine.

When your dog is suffering from any of the above, it doesn’t necessarily mean that gluten is inflicting it. It’s essential to consult with a veterinarian to seek out what is the precise cause.

Canine with epilepsy

More lately, a attainable hyperlink has been proven between gluten and epilepsy in canine (63, 64). Antibodies produced in response to gluten might act as a set off to seizures in canine. But additional analysis is needed as the design of those research might provide false positives (65).

Finally, an analogous correlation between epilepsy and gluten has been noticed in some human studies too, but extra evidence would assist to attract a full picture (66, 67, 68).

Abstract: Research present that a gluten free pet food weight loss plan might help pets with allergic reactions to gluten, epileptic canine and breeds which might be genetically predisposed to gluten sensitivity.

The best way to Know if a Dog Has Gluten Sensitivity

Diagnosing gluten sensitivity in canine is feasible, nevertheless it takes time to be utterly sure. Relating to dog food allergic reactions, there are two choices: blood checks and meals trials.

Blood testing is principally inaccurate in diagnosing food allergic reactions in canine (69, 70).

Many veterinarians will advise that the greatest strategy to determine if gluten is the causative factor of a canine’s allergy is with an elimination food regimen (71, 72).

The way to use elimination food plan

Dog elimination diets normally last from 6 to 12 weeks and have to be very strict. Your vet and nutritionist will help to determine an applicable dietary regime and the suitable gluten free dog food that does not include any allergens.

It will have to be trialed over a time period to see if dog’s allergy signs enhance. For the interval of trial feeding, your pets completely can’t eat any dog treats, rawhide, pig ears or flavored drugs; solely particular meals.

Research have shown that business grain free and gluten free dog food brands might help with a more accurate evaluation in the elimination food regimen challenge since most individuals can’t do selfmade dog food proper (73).

For canine which might be exhibiting pores and skin related symptoms, patch testing can also be carried out to additional conclude causes of food allergic reactions (74, 75).

Summary: Elimination food regimen is the one method to discover out whether a canine is delicate to gluten. These diets last 6-12 weeks and have to be very strict.

Why is There Gluten in Dog Food?

Since gluten isn’t harmful to most canine, it only is sensible to use it in dog food from the viewpoint of sustainability in specific instances (76, 77, 78).

Aside from contributing in the direction of the nutritional make-up of a dog food, gluten acts as a binding agent. It binds every part in a dry dog food together in order that it may be easily made into kibble.

Although elements that include gluten usually are not an issue in principal, gluten should not be used as an alternative to different good high quality protein sources. Reading lists of components on dog food labels will help determine if gluten has been used to increase the levels of protein in its make up.

Some manufacturers use gluten as an affordable substitute for animal protein, and people dog food manufacturers must be prevented for more than this purpose alone.

Larger quality components in gluten free pet food

One perceived advantage to feeding a grain free or gluten free pet food food regimen is the quality of components in these meals. This additionally may be true for sources of protein utilized in canine meals since they’re more likely to be of higher high quality and clearly recognized.

General, grain free canine foods are additionally more likely to include larger levels of protein. This isn’t shocking, since adding gluten in dog meals – even if it’s by no means dangerous to most canines – is a less expensive strategy to manufacture canine feed (76, 77, 78).

A gluten free food regimen might range from a selfmade canine weight-reduction plan formulated by a veterinary nutritionist to one of the many business gluten free dog food brands presently out there.

A few brands that manufacture gluten free canine foods are:

Studies have shown that opting for a business pet food eating regimen is more likely to benefit canines greater than selecting selfmade canine meals (79, 80, 81, 82, 83, 84).

Making a nutritionally well-balanced do-it-yourself dog food is a difficult enterprise as is, but making certain it’s additionally gluten free provides yet another step to complicate things even additional. But it’s doable.

Summary: Sustainability in the pet meals business issues. Gluten isn’t harmful to most canine, and it acts as a binding agent in kibble. Gluten free pet food might have larger quality components and higher levels of protein.

Gluten Free Meals for a Selfmade Food regimen

For those who choose to keep away from business gluten free canine meals and opt for making your personal do-it-yourself gluten free dog food, there are some things you want to concentrate on.

To begin with, studying labels of each food you purchase in your canine is key. All the time choose naturally gluten free foods as an alternative of processed foods with a “gluten free” label.

Foods to avoid

Here’s an inventory of commonest foods with gluten your canine must keep away from:

  • Processed foods
  • Baked goods
  • Wheat (all types)
  • Bread
  • Cereals
  • Couscous
  • Triticale
  • Rye
  • Einkorn
  • Barley
  • Pasta
  • Spelt
  • Desserts

A lot of these meals shouldn’t be in your pet’s eating regimen in the first place, nevertheless it’s notably necessary to keep away from them for canine with gluten sensitivity. Certain meals might be processed in the same facility as gluten (85). All the time learn labels.

Pure foods to include

Right here’s an inventory of meals which might be gluten free which you should use in selfmade dog food:

  • Meat
  • Fish
  • Seafood
  • Corn
  • Oats (gluten free)
  • Fruits
  • Greens
  • Rice
  • Buckwheat
  • Eggs
  • Nuts
  • Amaranth
  • Quinoa
  • Millet
  • Legumes
  • Sorghum
  • Oils and fats
  • Tapioca
  • Arrowroot

Keep in mind that canine can’t eat some of the fruits, greens, nuts, oils or grains within the category, so decide only those which might be wholesome and could be tolerated by a canine’s body.

Canine on a do-it-yourself weight-reduction plan can also need certain supplements for complete stability.

Vets also advocate adding a every day probiotic for canine. Many human studies discovered that probiotics will help with processing gluten and inhibiting gluten induced injury (86, 87, 88). We’re also aware of the various benefits of probiotics for canines and how they will improve intestine well being and strengthen the immune system in canine (89, 90, 91).

Abstract: There are plenty of pure foods which are gluten free which can be utilized in do-it-yourself pet food weight loss plan. Reading labels and including dietary supplements for an entire nutritional stability is necessary.

Take House Message

Gluten is a family of proteins, and acts as a binding agent to type kibble.

Most canine gained’t have any uncomfortable side effects from gluten when it’s a part of a nutritionally balanced food plan. A very small proportion of canine and some breeds particularly are affected by gluten sensitivities. In this group of canine, a gluten free dog food food plan may be extraordinarily useful.

The easiest way to know if a canine has gluten sensitivity is thru elimination food regimen. Research have additionally shown that gluten free dog food food regimen might profit canines with epilepsy.

Although there’s no purpose to buy gluten free pet food for healthy pets, it’s potential that this sort of pet food might have greater levels of protein and higher quality components.


  1. Wieser H. Relation between gliadin construction and coeliac toxicity. Acta Paediatr Suppl. 1996 Might;412:3-9.
  2. Wieser H. Chemistry of gluten proteins. Food Microbiol. 2007 Apr;24(2):115-9. Epub 2006 Sep 7.
  3. Tilley KA1, Benjamin RE, Bagorogoza KE, Okot-Kotber BM, Prakash O, Kwen H. Tyrosine cross-links: molecular foundation of gluten construction and function. J Agric Food Chem. 2001 Might;49(5):2627-32.
  4. Sapone A1, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou M, Kaukinen Okay, Rostami Okay, Sanders DS, Schumann M, Ullrich R, Villalta D, Volta U, Catassi C, Fasano A. Spectrum of gluten-related issues: consensus on new nomenclature and classification. BMC Med. 2012 Feb 7;10:13. doi: 10.1186/1741-7015-10-13.
  5. Rubio-Tapia A1, Ludvigsson JF, Brantner TL, Murray JA, Everhart JE. The prevalence of celiac illness in the USA. Am J Gastroenterol. 2012 Oct;107(10):1538-44; quiz 1537, 1545. doi: 10.1038/ajg.2012.219. Epub 2012 Jul 31.
  6. Castillo NE1, Theethira TG1, Leffler DA2. The present and the longer term in the analysis and management of celiac illness. Gastroenterol Rep (Oxf). 2015 Feb;3(1):3-11. doi: 10.1093/gastro/gou065. Epub 2014 Oct 17.
  7. Rubio-Tapia A1, Hill ID, Kelly CP, Calderwood AH, Murray JA; American School of Gastroenterology. ACG medical tips: analysis and management of celiac disease. Am J Gastroenterol. 2013 Might;108(5):656-76; quiz 677. doi: 10.1038/ajg.2013.79. Epub 2013 Apr 23.
  8. Nadhem ON1, Azeez G, Smalligan RD, Urban S. Evaluation and follow tips for celiac disease in 2014. Postgrad Med. 2015 Apr;127(3):259-65. doi: 10.1080/00325481.2015.1015926. Epub 2015 Feb 23.
  9. Corrao G1, Corazza GR, Bagnardi V, Brusco G, Ciacci C, Cottone M, Sategna Guidetti C, Usai P, Cesari P, Pelli MA, Loperfido S, Volta U, Calabró A, Certo M; Membership del Tenue Research Group. Mortality in sufferers with coeliac illness and their family members: a cohort research. Lancet. 2001 Aug Four;358(9279):356-61.
  10. van Heel DA1, West J. Current advances in coeliac illness. Gut. 2006 Jul;55(7):1037-46.
  11. Gujral N1, Freeman HJ, Thomson AB. Celiac disease: prevalence, analysis, pathogenesis and remedy. World J Gastroenterol. 2012 Nov 14;18(42):6036-59. doi: 10.3748/wjg.v18.i42.6036.
  12. Fasano A1, Sapone A2, Zevallos V3, Schuppan D4. Nonceliac gluten sensitivity. Gastroenterology. 2015 Might;148(6):1195-204. doi: 10.1053/j.gastro.2014.12.Zero49. Epub 2015 Jan 9.
  13. Molina-Infante J1, Santolaria S, Sanders DS, Fernández-Bañares F. Systematic evaluation: noncoeliac gluten sensitivity. Aliment Pharmacol Ther. 2015 Might;41(9):807-20. doi: 10.1111/apt.13155. Epub 2015 Mar 6.
  14. Mansueto P1, Seidita A, D’Alcamo A, Carroccio A. Non-celiac gluten sensitivity: literature assessment. J Am Coll Nutr. 2014;33(1):39-54. doi: 10.1080/07315724.2014.869996.
  15. Czaja-Bulsa G1. Non coeliac gluten sensitivity – A new disease with gluten intolerance. Clin Nutr. 2015 Apr;34(2):189-94. doi: 10.1016/j.clnu.2014.08.Zero12. Epub 2014 Aug 29.
  16. Hadjivassiliou M1, Sanders DS, Grünewald RA, Woodroofe N, Boscolo S, Aeschlimann D. Gluten sensitivity: from intestine to mind. Lancet Neurol. 2010 Mar;9(3):318-30. doi: 10.1016/S1474-4422(09)70290-X.
  17. Capannolo A1, Viscido A, Barkad MA, Valerii G, Ciccone F, Melideo D, Frieri G, Latella G. Non-Celiac Gluten Sensitivity among Patients Perceiving Gluten-Associated Symptoms. Digestion. 2015;92(1):Eight-13. doi: 10.1159/000430090. Epub 2015 Might 30.
  18. Zuidmeer L1, Goldhahn Okay, Rona RJ, Gislason D, Madsen C, Summers C, Sodergren E, Dahlstrom J, Lindner T, Sigurdardottir ST, McBride D, Keil T. The prevalence of plant meals allergic reactions: a systematic evaluation. J Allergy Clin Immunol. 2008 Might;121(5):1210-1218.e4. doi: 10.1016/j.jaci.2008.02.019. Epub 2008 Apr 18.
  19. Shanti Eswaran, MD, Akash Goel, MD, William D. Chey, MD. What Position Does Wheat Play in the Signs of Irritable Bowel Syndrome? Gastroenterol Hepatol (N Y). 2013 Feb; 9(2): 85–91.
  20. Makharia A1, Catassi C2, Makharia GK1. The Overlap between Irritable Bowel Syndrome and Non-Celiac Gluten Sensitivity: A Medical Dilemma. Vitamins. 2015 Dec 10;7(12):10417-26. doi: 10.3390/nu7125541.
  21. Biesiekierski JR1, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR. Gluten causes gastrointestinal signs in subjects without celiac illness: a double-blind randomized placebo-controlled trial. Am J Gastroenterol. 2011 Mar;106(3):508-14; quiz 515. doi: 10.1038/ajg.2010.487. Epub 2011 Jan 11.
  22. Vazquez-Roque MI1, Camilleri M, Smyrk T, Murray JA, Marietta E, O’Neill J, Carlson P, Lamsam J, Janzow D, Eckert D, Burton D, Zinsmeister AR. A controlled trial of gluten-free food regimen in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal perform. Gastroenterology. 2013 Might;144(5):903-911.e3. doi: 10.1053/j.gastro.2013.01.Zero49. Epub 2013 Jan 25.
  23. Aziz I1, Trott N2, Briggs R2, North JR2, Hadjivassiliou M2, Sanders DS2. Efficacy of a Gluten-Free Food plan in Topics With Irritable Bowel Syndrome-Diarrhea Unaware of Their HLA-DQ2/Eight Genotype. Clin Gastroenterol Hepatol. 2015 Dec 31. pii: S1542-3565(15)01715-2. doi: 10.1016/j.cgh.2015.12.031. [Epub ahead of print]
  24. Matteo Cerquetella, Andrea Spaterna, Fulvio Laus, Beniamino Tesei, Giacomo Rossi, Elisabetta Antonelli, Vincenzo Villanacci, Gabrio Bassotti. Inflammatory bowel disease within the dog: Differences and similarities with people. World J Gastroenterol. 2010 Mar 7; 16(9): 1050–1056. Revealed online 2010 Mar 7. doi: 10.3748/wjg.v16.i9.1050
  25. Jergens AE1, Simpson KW. Inflammatory bowel disease in veterinary drugs. Front Biosci (Elite Ed). 2012 Jan 1;Four:1404-19.
  26. Malewska K1, Rychlik A, Nieradka R, Kander M. Remedy of inflammatory bowel disease (IBD) in canine and cats. Pol J Vet Sci. 2011;14(1):165-71.
  27. Simpson JW1. Eating regimen and enormous intestinal disease in canine and cats. J Nutr. 1998 Dec;128(12 Suppl):2717S-2722S.
  28. Angelucci E1, Malesci A, Danese S. Budesonide: educating an previous dog new tips for inflammatory bowel disease remedy. Curr Med Chem. 2008;15(24):2527-35.
  29. Eric V. Marietta, PhD, Joseph A. Murray, MD. Animal Models to Research Gluten Sensitivity. Semin Immunopathol. Writer manuscript; out there in PMC 2013 Jul 1. Revealed in remaining edited type as: Semin Immunopathol. 2012 Jul; 34(4): 497–511. Revealed on-line 2012 Might 11. doi: 10.1007/s00281-012-0315-y.
  30. Batt RM, Carter MW, McLean L. Morphological and biochemical studies of a naturally occurring enteropathy in the Irish setter canine: a comparability with coeliac disease in man. Res Vet Sci. 1984 Nov;37(3):339-46.
  31. E J Corridor, R M Batt. Dietary modulation of gluten sensitivity in a naturally occurring enteropathy of Irish setter canine. Intestine. 1992 Feb; 33(2): 198–205.
  32. Margaret A Maglione, MPP, Adeyemi Okunogbe, MBChB, Brett Ewing, MS, Sean Grant, PhD, Sydne J Newberry, PhD, Aneesa Motala, BA, Roberta Shanman, MLS, Nelly Mejia, MPhil, Aziza Arifkhanova, MS, Paul Shekelle, MD, PhD, and Gregory Harmon, MD. Analysis of Celiac Illness. Comparative Effectiveness Evaluations, No. 162. Rockville (MD): Company for Healthcare Research and High quality (US); 2016 Jan. Report No.: 15(16)-EHC032-EF.
  33. Rostom A, Dubé C, Cranney A, Saloojee N, Sy R, Garritty C, Sampson M, Zhang L, Yazdi F, Mamaladze V, Pan I, McNeil J, Moher D, Mack D, Patel D. Celiac illness. Evid Rep Technol Assess (Summ). 2004 Jun;(104):1-6.
  34. Ishida R1, Masuda Okay, Kurata Okay, Ohno Okay, Tsujimoto H. Lymphocyte blastogenic responses to inciting meals allergens in canine with meals hypersensitivity. J Vet Intern Med. 2004 Jan-Feb;18(1):25-30.
  35. Paterson S1. Food hypersensitivity in 20 canine with pores and skin and gastrointestinal indicators. J Small Anim Pract. 1995 Dec;36(12):529-34.
  36. Marcason W1. What’s the FODMAP weight-reduction plan? J Acad Nutr Eating regimen. 2012 Oct;112(10):1696. doi: 10.1016/j.jand.2012.08.005.
  37. Biesiekierski JR1, Peters SL, Newnham ED, Rosella O, Muir JG, Gibson PR. No effects of gluten in sufferers with self-reported non-celiac gluten sensitivity after dietary discount of fermentable, poorly absorbed, short-chain carbohydrates. Gastroenterology. 2013 Aug;145(2):320-8.e1-Three. doi: 10.1053/j.gastro.2013.04.051. Epub 2013 Might 4.
  38. Fardet A1. New hypotheses for the health-protective mechanisms of whole-grain cereals: what’s past fibre? Nutr Res Rev. 2010 Jun;23(1):65-134. doi: 10.1017/S0954422410000041. Epub 2010 Jun 22.
  39. Bethune MT1, Borda JT, Ribka E, Liu MX, Phillippi-Falkenstein Okay, Jandacek RJ, Doxiadis GG, Grey GM, Khosla C, Sestak Okay. A non-human primate mannequin for gluten sensitivity. PLoS One. 2008 Feb 20;3(2):e1614. doi: 10.1371/journal.pone.0001614.
  40. Lowrie M1, Backyard OA2, Hadjivassiliou M3, Harvey RJ4, Sanders DS5, Powell R6, Garosi L1. The Medical and Serological Impact of a Gluten-Free Food plan in Border Terriers with Epileptoid Cramping Syndrome. J Vet Intern Med. 2015 Nov-Dec;29(6):1564-Eight. doi: 10.1111/jvim.13643. Epub 2015 Oct 25.
  41. Pemberton PW1, Lobley RW, Holmes R, Sørensen SH, Batt RM. Gluten-sensitive enteropathy in Irish setter canine: characterisation of jejunal microvillar membrane proteins by two-dimensional electrophoresis. Res Vet Sci. 1997 Mar-Apr;62(2):191-3.
  42. EV Marietta, CS David, JA Murray. Necessary Lessons Derived From Animal Models of Celiac Disease. Int Rev Immunol. Writer manuscript; out there in PMC 2012 Oct 24. Revealed in ultimate edited type as: Int Rev Immunol. 2011 Aug; 30(Four): 197–206. doi: 10.3109/08830185.2011.598978
  43. Knibb RC1, Armstrong A, Booth DA, Platts RG, Sales space IW, MacDonald A. Psychological traits of individuals with perceived meals intolerance in a group pattern. J Psychosom Res. 1999 Dec;47(6):545-54.
  44. Younger E1, Stoneham MD, Petruckevitch A, Barton J, Rona R. A population research of meals intolerance. Lancet. 1994 Might 7;343(8906):1127-30.
  45. Woods RK, Stoney RM, Raven J, et al. (2002) Reported food reactions overestimate true food allergy locally. Eur J Clin Nutr 56:31-36
  46. Axelsson E1, Ratnakumar A, Arendt ML, Maqbool Okay, Webster MT, Perloski M, Liberg O, Arnemo JM, Hedhammar A, Lindblad-Toh Okay. The genomic signature of canine domestication reveals adaptation to a starch-rich food regimen. Nature. 2013 Mar 21;495(7441):360-Four. doi: 10.1038/nature11837. Epub 2013 Jan 23.
  47. Ann Wortinger (2005) Dietary Myths. Journal of the American Animal Hospital Association: July/August 2005, Vol. 41, No. 4, pp. 273-276.
  48. Kennis RA1. Meals allergic reactions: replace of pathogenesis, diagnoses, and administration. Vet Clin North Am Small Anim Pract. 2006 Jan;36(1):175-84, vii-viii.
  49. Hall EJ1, Batt RM. Irregular permeability precedes the development of a gluten delicate enteropathy in Irish setter canine. Intestine. 1991 Jul;32(7):749-53.
  50. Backyard OA1, Pidduck H, Lakhani KH, Walker D, Wooden JL, Batt RM. Inheritance of gluten-sensitive enteropathy in Irish Setters. Am J Vet Res. 2000 Apr;61(Four):462-8.
  51. S C Daminet. Gluten-sensitive enteropathy in a family of Irish setters. Can Vet J. 1996 Dec; 37(12): 745–746.
  52. German AJ1, Hall EJ, Day MJ. Continual intestinal irritation and intestinal illness in canine. J Vet Intern Med. 2003 Jan-Feb;17(1):Eight-20.
  53. Elwood CM, Moore PF, Batt RM. (2001) Expression of gluten sensitive enteropathy (GSE) of Irish Setter canine may be age dependent. J Vet Intern Med;15:274.
  54. Batt RM, Carter MW, McLean L. Wheat-sensitive enteropathy in Irish setter canine: attainable age-related brush border abnormalities. Res Vet Sci. 1985 Jul;39(1):80-3.
  55. Polvi A1, Backyard OA, Houlston RS, Maki M, Batt RM, Partanen J. Genetic susceptibility to gluten sensitive enteropathy in Irish setter canine shouldn’t be linked to the main histocompatibility complicated. Tissue Antigens. 1998 Dec;52(6):543-9.
  56. Vaden SL1, Sellon RK, Melgarejo LT, Williams DA, Trogdon MM, VanCamp SD, Argenzio RA. Analysis of intestinal permeability and gluten sensitivity in Smooth-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both. Am J Vet Res. 2000 Might;61(5):518-24.
  57. Littman, M. P., &#Zero38; Giger, U. (1990). Familial protein-losing enteropathy (PLE) and/or protein-losing nephropathy (PLN) in Delicate-coated Wheaten Terriers (SCWT). In ACVIM Abstr (Vol. 1135).
  58. Vaden SL1, Hammerberg B, Davenport DJ, Orton SM, Trogdon MM, Melgarejo LT, VanCamp SD, Williams DA. Meals hypersensitivity reactions in Gentle Coated Wheaten Terriers with protein-losing enteropathy or protein-losing nephropathy or each: gastroscopic meals sensitivity testing, dietary provocation, and fecal immunoglobulin E. J Vet Intern Med. 2000 Jan-Feb;14(1):60-7.
  59. Littman MP1, Dambach DM, Vaden SL, Giger U. Familial protein-losing enteropathy and protein-losing nephropathy in Tender Coated Wheaten Terriers: 222 instances (1983-1997). J Vet Intern Med. 2000 Jan-Feb;14(1):68-80.
  60. Black V1, Garosi L1, Lowrie M1, Harvey RJ2, Gale J3. Phenotypic characterisation of canine epileptoid cramping syndrome in the Border terrier. J Small Anim Pract. 2014 Feb;55(2):102-7. doi: 10.1111/jsap.12170. Epub 2013 Dec 26.
  61. Carlotti, D. N., Remy, I. and Prost, C. (1990), Food Allergy In Canine And Cats. A Assessment and Report of 43 Instances. Veterinary Dermatology, 1: 55–62. doi: 10.1111/j.1365-3164.1990.tb00080.x
  62. Chesney CJ. Meals sensitivity within the dog: a quantitative research. J Small Anim Pract. 2002 Might;43(5):203-7.
  63. Newell GW, Erickson TC, et al. Effect of wheat gluten eating regimen on the electroencephalograms of canine. Proc Soc Exp Biol Med. 1947 Might;65(1):115.
  64. V Black, L Garosi, M Lowrie, R J Harvey, J Gale. Phenotypic characterisation of canine epileptoid cramping syndrome within the Border terrier. J Small Anim Pract. 2014 Feb; 55(2): 102–107. doi: 10.1111/jsap.12170
  65. Muñana KR1, Zhang D, Patterson EE. Placebo effect in canine epilepsy trials. J Vet Intern Med. 2010 Jan-Feb;24(1):166-70. doi: 10.1111/j.1939-1676.2009.0407.x.
  66. Mavroudi A1, Karatza E, Papastavrou T, Panteliadis C, Spiroglou Okay. Successful remedy of epilepsy and celiac disease with a gluten-free weight-reduction plan. Pediatr Neurol. 2005 Oct;33(4):292-5.
  67. Hugh J Freeman. Neurological issues in grownup celiac disease. Can J Gastroenterol. 2008 Nov; 22(11): 909–911.
  68. Canales P1, Mery VP, Larrondo FJ, Bravo FL, Godoy J. Epilepsy and celiac disease: favorable consequence with a gluten-free food regimen in a patient refractory to antiepileptic medicine. Neurologist. 2006 Nov;12(6):318-21.
  69. Jackson HA1, Jackson MW, Coblentz L, Hammerberg B. Analysis of the medical and allergen particular serum immunoglobulin E responses to oral problem with cornstarch, corn, soy and a soy hydrolysate food regimen in canine with spontaneous food allergy. Vet Dermatol. 2003 Aug;14(Four):181-7.
  70. Zimmer A1, Bexley J, Halliwell RE, Mueller RS. Food allergen-specific serum IgG and IgE before and after elimination diets in allergic canine. Vet Immunol Immunopathol. 2011 Dec 15;144(3-4):442-7. doi: 10.1016/j.vetimm.2011.09.001. Epub 2011 Sep 10.
  71. Jeffers JG1, Meyer EK, Sosis EJ. Responses of canine with meals allergic reactions to single-ingredient dietary provocation. J Am Vet Med Assoc. 1996 Aug 1;209(3):608-11.
  72. Harvey, R. G. (1993), Food allergy and dietary intolerance in canine: A report of 25 instances. Journal of Small Animal Apply, 34: 175–179. doi: 10.1111/j.1748-5827.1993.tb02647.x
  73. Tapp T1, Griffin C, Rosenkrantz W, Muse R, Boord M. Comparability of a business limited-antigen food regimen versus home-prepared diets in the analysis of canine opposed meals response. Vet Ther. 2002 Fall;3(Three):244-51.
  74. Bethlehem S1, Bexley J, Mueller RS. Patch testing and allergen-specific serum IgE and IgG antibodies in the analysis of canine opposed food reactions. Vet Immunol Immunopathol. 2012 Feb 15;145(3-Four):582-9. doi: 10.1016/j.vetimm.2012.01.003. Epub 2012 Jan 12.
  75. Olivry T1, Deangelo KB, Dunston SM, Clarke KB, McCall CA. Patch testing of experimentally sensitized beagle canine: improvement of a mannequin for pores and skin lesions of atopic dermatitis. Vet Dermatol. 2006 Apr;17(2):95-102.
  76. Kelly S. Swanson, Rebecca A. Carter, Tracy P. Yount, Jan Aretz, Preston R. Buff. Nutritional Sustainability of Pet Foods. Adv Nutr. 2013 Mar; 4(2): 141–150. Revealed online 2013 Mar 6. doi: 10.3945/an.112.003335
  77. Deng P, Swanson KS. COMPANION ANIMALS SYMPOSIUM: Future features and perceptions of companion animal vitamin and sustainability. J Anim Sci. 2015 Mar;93(3):823-34. doi: 10.2527/jas.2014-8520.
  78. Swanson KS1, Carter RA, Yount TP, Aretz J, Buff PR. Dietary sustainability of pet meals. Adv Nutr. 2013 Mar 1;4(2):141-50. doi: 10.3945/an.112.003335.
  79. Stockman J1, Fascetti AJ, Kass PH, Larsen JA. Analysis of recipes of home-prepared maintenance diets for canine. J Am Vet Med Assoc. 2013 Jun 1;242(11):1500-5. doi: 10.2460/javma.242.11.1500.
  80. Larsen JA1, Parks EM, Heinze CR, Fascetti AJ. Analysis of recipes for home-prepared diets for canine and cats with persistent kidney disease. J Am Vet Med Assoc. 2012 Mar 1;240(5):532-8. doi: 10.2460/javma.240.5.532.
  81. Roudebush, P. and Cowell, C. S. (1992), Outcomes of a Hypoallergenic Eating regimen Survey of Veterinarians in North America with a Nutritional Analysis of Selfmade Weight-reduction plan Prescriptions. Veterinary Dermatology, Three: 23–28. doi: 10.1111/j.1365-3164.1992.tb00139.x
  82. Taylor MB1, Geiger DA, Saker KE, Larson MM. Diffuse osteopenia and myelopathy in a pet fed a weight-reduction plan composed of an natural premix and raw ground beef. J Am Vet Med Assoc. 2009 Apr 15;234(Eight):1041-8. doi: 10.2460/javma.234.Eight.1041.
  83. Freeman LM1, Michel KE. Analysis of raw meals diets for canine. J Am Vet Med Assoc. 2001 Mar 1;218(5):705-9.
  84. Heinze CR1, Gomez FC, Freeman LM. Assessment of economic diets and recipes for home-prepared diets advisable for canine with cancer. J Am Vet Med Assoc. 2012 Dec 1;241(11):1453-60. doi: 10.2460/javma.241.11.1453.
  85. Francavilla R, Cristofori F, Stella M, Borrelli G, Naspi G, Castellaneta S. Remedy of celiac disease: from gluten-free food regimen to novel therapies. Minerva Pediatr. 2014 Oct;66(5):501-16.
  86. de Sousa Moraes LF1, Grzeskowiak LM2, de Sales Teixeira TF2, Gouveia Peluzio Mdo C2. Intestinal microbiota and probiotics in celiac illness. Clin Microbiol Rev. 2014 Jul;27(Three):482-9. doi: 10.1128/CMR.00106-13.
  87. Okay Lindfors, T Blomqvist, Okay Juuti-Uusitalo, S Stenman, J Venäläinen, M Mäki, Okay Kaukinen. Stay probiotic Bifidobacterium lactis bacteria inhibit the poisonous results induced by wheat gliadin in epithelial cell tradition. Clin Exp Immunol. 2008 Jun; 152(3): 552–558. doi: 10.1111/j.1365-2249.2008.03635.x
  88. Lorenzo Pisarello MJ1, Vintiñi EO, González SN, Pagani F, Medina MS. Decrease in lactobacilli within the intestinal microbiota of celiac youngsters with a gluten-free eating regimen, and number of probably probiotic strains. Can J Microbiol. 2015 Jan;61(1):32-7. doi: 10.1139/cjm-2014-0472.
  89. Baillon ML1, Marshall-Jones ZV, Butterwick RF. Results of probiotic Lactobacillus acidophilus pressure DSM13241 in wholesome adult canine. Am J Vet Res. 2004 Mar;65(Three):338-43.
  90. Grześkowiak Ł1, Endo A2, Beasley S3, Salminen S4. Microbiota and probiotics in canine and feline welfare. Anaerobe. 2015 Aug;34:14-23. doi: 10.1016/j.anaerobe.2015.04.002. Epub 2015 Apr Eight.
  91. Kelley RL1, Minikhiem D, Kiely B, O’Mahony L, O’Sullivan D, Boileau T, Park JS. Medical advantages of probiotic canine-derived Bifidobacterium animalis strain AHC7 in canine with acute idiopathic diarrhea. Vet Ther. 2009 Fall;10(Three):121-30.